Description: Verruculogen, a toxin primarily produced by Penicillium and Aspergillus spp., inhibits Ca2+-activated K+ channels and acts as an M phase inhibitor of the mammalian cell cycle. Target: Others. Smiles: [H][C@@]12CCCN1C(=O)[C@]1(O)[C@@H](O)c3c4n([C@H](OOC(C)(C)C[C@]4([H])N1C2=O)C=C(C)C)c1cc(OC)ccc31....

Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium, Aspergillus, and other fungi. It selectively inhibits the activation of large-conductance calcium-activated potassium channels (KCa1.1/BK) potassium channels by charybdotoxin with a K1/2 value of 170 nM. Verruculogen also promotes the...

White to off-white solid. Soluble in DMSO, 100% ethanol, methanol or dichloromethane. Fumitremorgin-type alkaloid, Tremorgenic neurotoxic mycotoxin, Selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK, maxi-K) channels, Decreases GABA levels in CNS, Increases spontaneous glutamate and aspartate...

A tremorgenic neurochemical produced by various soil fungi.

Verruculogen is a tremorgenic mycotoxin first isolated from Penicillium verruculosum in 1972 and the structure resolved as an indole alkaloid in 1974. Subsequent investigations have shown that verruculogen is produced by several species of Penicillium and Aspergillus and its presence is a useful taxonomic phenotypic...