UNC3866

UNC3866 is an inhibitor of chromobox homolog 7 (CBX7, Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 µM). UNC3866 pretreatment (30 µM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 µM.Formal Name: N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine, methyl ester. CAS Number: 1872382-47-2. Molecular Formula: C43H66N6O8. Formula Weight: 795.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMSO: 33 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml, Ethanol: 16 mg/ml. lambdamax: 240 nm. SMILES: CC(C)(C1=CC=C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(OC)=O)CO)=O)CCCCN(CC)CC)=O)CC(C)C)=O)C)=O)CC2=CC=CC=C2)=O)C=C1)C. InChi Code: InChI=1S/C43H66N6O8/c1-10-49(11-2)24-16-15-19-33(39(53)48-36(27-50)42(56)57-9)45-41(55)34(25-28(3)4)46-37(51)29(5)44-40(54)35(26-30-17-13-12-14-18-30)47-38(52)31-20-22-32(23-21-31)43(6,7)8/h12-14,17-18,20-23,28-29,33-36,50H,10-11,15-16,19,24-27H2,1-9. InChi Key: UMRRDXVUROEIKJ-JCXBGQGISA-N.