TDZD-8

TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3beta (GSK3beta, IC50 = 2 µM), binding to the active site of GSK3beta. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 µM). TDZD-8 has been used to study the role of GSK3beta during stem cell differentiation as well as in cell and animal models of Alzheimer's disease and other neurodegenerative disorders.Formal Name: 2-methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione. CAS Number: 327036-89-5. Synonyms: GSK3beta Inhibitor I, NP 01139. Molecular Formula: C10H10N2O2S. Formula Weight: 222.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 238 nm. SMILES: O=C1SN(C)C(N1CC2=CC=CC=C2)=O. InChi Code: InChI=1S/C10H10N2O2S/c1-11-9(13)12(10(14)15-11)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3. InChi Key: JDSJDASOXWCHPN-UHFFFAOYSA-N.