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The mouse constitutive androstane receptor (mCAR), with the retinoid X receptor, binds to the retinoic acid response element to upregulate the expression of proteins that metabolize xenobiotics. TCPOBOP is an agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR receptors. Through its effects on mCAR, TCPOBOP potently induces cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins. The action of TCPOBOP on mCAR-mediated gene expression can be repressed by retinoic acids.Formal Name: 2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro]-pyridine. CAS Number: 76150-91-9. Molecular Formula: C16H8Cl4N2O2. Formula Weight: 402.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml. lambdamax: 235, 290 nm. SMILES: ClC1=CN=C(OC2=CC=C(OC3=C(Cl)C=C(Cl)C=N3)C=C2)C(Cl)=C1. InChi Code: InChI=1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H. InChi Key: BAFKRPOFIYPKBQ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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