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Item number: TGM-T17018-100mg

Description: TCPOBOP, a constitutive androstane receptor agonist, induces robust hepatocyte proliferation and hepatomegaly while decreasing Fas-induced murine liver injury by altering Bcl-2 proteins. Target: BCL. Smiles: Clc1cnc(Oc2ccc(Oc3ncc(Cl)cc3Cl)cc2)c(Cl)c1. References: Bhushan B, et al. TCPOBOP-Induced...

Application:	Mouse CAR agonist
CAS	76150-91-9
MW:	402.06 D

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TCPOBOP

Item number: Cay14140-5

The mouse constitutive androstane receptor (mCAR), with the retinoid X receptor, binds to the retinoic acid response element to upregulate the expression of proteins that metabolize xenobiotics. TCPOBOP is an agonist for mCAR (EC50 = 20 nM) that is effective for the mouse receptor but not for human or rat CAR...

Keywords:	2,2'-[1,4-phenylenebis(oxy)]bis[3,5-dichloro]-pyridine
Application:	Mouse CAR agonist
CAS	76150-91-9
MW:	402.1 D

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