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SR 717 is an agonist of stimulator of interferon genes (STING, EC50 = 2.1 µM in a reporter assay). It is selective for STING over a panel of 468 kinases. SR 717 (30 mg/kg, i.p.) increases plasma IFN-beta and IL-6 levels in mice. It also increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model.Formal Name: 4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-benzoic acid, monolithium salt. CAS Number: 2375421-09-1. Molecular Formula: C15H8F2N5O3 . Li. Formula Weight: 351.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml. lambdamax: 238, 290 nm. SMILES: O=C([O-])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O.[Li+]. InChi Code: InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22,/h1-7H,(H,19,23)(H,24,25),/q,+1/p-1. InChi Key: ODSAJRWPLSVEHJ-UHFFFAOYSA-M.
Keywords:
4,5-difluoro-2-[[[6-(1H-imidazol-1-yl)-3-pyridazinyl]carbonyl]amino]-benzoic acid, monolithium salt
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