104 products were found matching "K12654"!

PDIC-NS is an activator of stimulator of interferon genes (STING). It increases the levels of reactive oxygen species (ROS) and induces apoptosis in LL/2 lung carcinoma cells when used at a concentration of 2.5 µM. PDIC-NS (2.5 µM) induces cell cycle arrest at the S phase, increases cytosolic levels of mitochondrial...

STING PROTAC SP23 is a proteolysis-targeting chimera (PROTAC) containing the stimulator of interferon genes (STING) inhibitor C-170 (Cay-30157) conjugated to the cereblon (CRBN) inhibitor pomalidomide (Cay-19877) via an alpha,beta-unsaturated carbonyl linker. It degrades STING in THP-1 cells with a half-maximal...

BDW568 is an agonist of stimulator of interferon genes (STING) and a prodrug form of BDW-OH. It induces STING transcriptional activity in a reporter assay using THP-1 cells (EC50 = 7.6 µM). BDW568 (50 µM) induces phosphorylation of TANK-binding kinase 1 (TBK1) and IFN regulatory factor 3 (IRF3) in THP-1 cells.Formal...

LB244 is an irreversible STING antagonist. It binds to STING in a cell-free assay and inhibits STING activation induced by the STING agonist diABZI in cells (EC50 = 0.8 nM). LB244 (1 µM) inhibits diABZI-induced STING oligomerization and phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1...

STING agonist D61 (D61) is an agonist of stimulator of interferon genes (STING). It induces expression of an IFN3-inducible secreted alkaline phosphatase (SEAP) reporter gene and an IFN-beta-inducible reporter gene in cell-based assays (EC50s = 52.9 and 116 nM, respectively). D61 (4, 6, and 8 µM) increases the...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TMEM173. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TMEM173....

STING agonist 12L is an agonist of stimulator of interferon genes (STING). It binds to wild-type STING (IC50 = 1.15 µM), as well as the STING R232, AQ, and Q variants (IC50s = 1.06, 0.61, and 1.12 µM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC50s = 0.38 and 12.94 µM,...

SN-001 is an inhibitor of stimulator of interferon genes (STING). It inhibits herring testis DNA-induced Ifnb mRNA expression in L-929 cells (IC50 = 3.82 µM).Formal Name: N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-methoxyphenyl]-[1,1'-biphenyl]-4-carboxamide. CAS Number: 727699-84-5. Synonyms: DUN99845, Stimulator of...

BSP-16 is a stimulator of interferon genes (STING) agonist. It binds to STING (Kd = 23 µM) and induces the production of IFN-beta, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3...

STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB...

STING agonist 23 is an agonist of stimulator of interferon genes (STING). It increases the phosphorylation of TANK-binding kinase 1 (TBK1) in wild-type, but not STING-deficient, HT-1080 cells when used at a concentration of 20 µM. STING agonist 23 induces dimerization of STING in THP-1 cells and mouse bone...

H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in...