199 products were found matching "K12654"!

STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second...

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. STING1 antibody detects Stimulator of interferon genes (TMEM173), a central adaptor protein in the cytosolic DNA-sensing pathway that activates type I interferon responses. The UniProt recommended name is Stimulator of interferon genes...

SNX-281 is an agonist of stimulator of interferon genes (STING). InChI: InChI=1S/C20H20ClNO3S/c1-20(2,3)11-5-6-12-15(9-11)22(10-16(23)24)17-13(18(12)25)7-8-14(21)19(17)26-4/h5-9H,10H2,1-4H3,(H,23,24) InChIKey: CLGJCTXUWJLYHO-UHFFFAOYSA-N SMILES: O=C(O)CN1C2=C(C(Cl)=CC=C2C(C3=CC=C(C=C31)C(C)(C)C)=O)SC

MK-2118 is an agonist of stimulator of interferon genes (STING). It induces STING signaling in a reporter assay using membranes expressing human STING (EC50 = 2. µM). MK-2118 (30 µM) induces IFN-beta secretion in THP-1 monocytes. InChI:...

Protein function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010,...

Protein function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (PubMed:18724357, PubMed:18818105, PubMed:19433799, PubMed:19776740, PubMed:23027953, PubMed:23910378, PubMed:23747010,...

Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant is the most common variant...

STING H232 variant, SUMO-tagged contains amino acids 155-341 of the H232 variant and a removable N-terminal SUMOpro tag. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-kappaB...

H-151 is an inhibitor of stimulator of interferon genes (STING). It forms an adduct with mouse STING in serum and acts in an irreversible manner. It inhibits the type I interferon (IFN) response and reduces the phosphorylation of TBK1 and palmitoylation of human STING (hsSTING) in vitro. It also reduces increases in...

diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-beta in human peripheral blood mononuclear cells (PBMCs, EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-beta, IL-6, TNF, and KC/GROalpha in wild-type, but not...

diABZI STING agonist 2 is an agonist of stimulator of interferon genes (STING). It binds to STING with an apparent Kd value of 1.6 nM. It is selective for STING over the acute phase reactant orosomucoid 1 (ORM1, apparent Kd = 79 nM). diABZI STING agonist 2 increases phosphorylation of interferon regulatory factor 3...