SR 12460

SR 12460 is a mimetic of the IkappaB kinase beta (IKKbeta) NEMO/IKKgamma-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-kappaB essential modulator (NEMO/IKKgamma) and IKKbeta. It inhibits TNF-alpha-induced NF-kappaB activation in a reporter assay when used at concentrations ranging from 25 to 150 µM. It reduces LPS-induced production of IL-6 in RAW 264.7 cells. SR 12460 (30 mg/kg) improves grip strength in the mdx mouse model of Duchenne muscular dystrophy.Formal Name: N-(5-chloro-2-pyridinyl)-2-[[2-(3,5-difluorophenyl)ethyl]amino]-acetamide. CAS Number: 2055101-66-9. Molecular Formula: C15H14ClF2N3O. Formula Weight: 325.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 15 mg/ml. lambdamax: 244, 288 nm. SMILES: FC1=CC(F)=CC(CCNCC(NC2=NC=C(C=C2)Cl)=O)=C1. InChi Code: InChI=1S/C15H14ClF2N3O/c16-11-1-2-14(20-8-11)21-15(22)9-19-4-3-10-5-12(17)7-13(18)6-10/h1-2,5-8,19H,3-4,9H2,(H,20,21,22). InChi Key: MQWIKNJATTZAPQ-UHFFFAOYSA-N.