117 products were found matching "K07209"!

BMS 345541 is a cell permeable inhibitor of the IkappaB kinases IKKalpha and IKKbeta (IC50s = 4 and 0.3 µM). It is without effect against a panel of other serine/threonine and tyrosine kinases at 100 µM. BMS 345541 inhibits signaling through nuclear factor-kappaB (NF-kappaB) both in cells and in vivo, showing...

White to off-white solid. Soluble in DMSO or 100% ethanol. Insoluble in water. Anti-inflammatory and anti-arthritic agent. Represses the activation of the NLRP3/IL-1beta pathway, Inhibitor of 5-lipoxygenase in human neutrophils, IKB kinase (IKK) by modifying Cys-179 of the IKKbeta subunit 5, Potent thioredoxin...

IKK-16 is a potent inhibitor of IkappaB kinases (IKKs), displaying IC50 values of 200, 40, and 70 nM for IKKalpha, IKKbeta, and IKK complex, respectively, in cell-free assays. It is effective in cells and in animals and has been used delineate the role of NF-kappaB signaling in diverse contexts. IKK-16 has also been...

BI-605906 is an inhibitor of inhibitor of kappa B kinase subunit beta (IKKbeta, IC50 = 380 nM). It is selective for IKKbeta over insulin-like growth factor 1 (IGF1, IC50 = 7.6 µM) and over 100 kinases in a panel up to 10 µM. BI-605906 partially inhibits IL-1-stimulated activation of IKKepsilon/TBK1 in vitro....

Description: SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 µM), obstructs NF-kappaB-dependent gene expression. Target: IkappaB/IKK, p38 MAPK, CDK, Aurora Kinase, Serine Protease. Smiles: NC(=O)c1sc(cc1N)-c1ccsc1. References: Kishore N, et al. J Biol Chem, 2003,...

SC-514 is a selective and reversible inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 3-12 µM) that displays greater than 10-fold selectivity over 28 other kinases, including JNK, p38, MK2, and ERK. In synovial fibroblasts stimulated with interleukin (IL)-1beta, SC-514 attenuates NF-kappaB-mediated expression of IL-6,...

Anti-IKKbeta Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with IKKbeta from Human and Mouse based on 100% homology with the immunizing sequence. Cross-reactivity withAnti-IKKbeta from other sources has not been determined. Protein function: Serine kinase...

PS-1145 is an IkappaB kinase beta (IKKbeta) inhibitor (IC50 = 88 nM). It selectively inhibits IKKbeta over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM). It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations...

IMD 0354 is an IKKbeta (IKK2) inhibitor that blocks NF-kappaB phosphorylation (IC50 = ~250 nM) and subsequent NF-kappaB p65 nuclear translocation. It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1beta and MCP-1 production,...

TPCA-1 is a selective inhibitor of IkappaB kinase-2 (IC50s = 17.9 nM and 0.40 µM for IKK2 and IKK1, respectively). Furthermore, it displays greater than 550-fold selectivity over other kinases and enzymes including, p38, MAPK, COX, and JNK. TPCA-1 inhibits the production of LPS-induced TNF-alpha, IL-6, and IL-8 with...

ACHP is an inhibitor of IkappaB kinase beta (IKKbeta) and IKKalpha (IC50s = 8.5 and 250 nM, respectively). It is selective for IKKbeta and IKKalpha over IKKgamma, Syk, and MKK4 (IC50s = >20 µM for all). It reduces the constitutive phosphorylation of IkappaBalpha and NF-kappaB p65 in U266 and NCU-MM-2 multiple...

Description: TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM), shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes. Target: Apoptosis, IkappaB/IKK, STAT. Smiles: NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1. References: Podolin PL, et al, J Pharmacol Exp...