Quinapril (hydrochloride)

Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200 mg/kg) prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations containing quinapril have been used in the treatment of hypertension, heart failure, and diabetic nephropathy.Formal Name: 2-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. CAS Number: 82586-55-8. Synonyms: CI-906, PD 109452-2. Molecular Formula: C25H30N2O5 . HCl. Formula Weight: 475.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 3.33 mg/ml. SMILES: O=C(OCC)[C@@H](N[C@@H](C)C(N1[C@H](C(O)=O)CC(C=CC=C2)=C2C1)=O)CCC3=CC=CC=C3.Cl. InChi Code: InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30,/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30),1H/t17-,21-,22-,/m0./s1. InChi Key: IBBLRJGOOANPTQ-JKVLGAQCSA-N.