Description: Quinapril hydrochloride (PD-109452-2) is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and congestive heart failure. Quinapril hydrochloride is associated with a low rate of transient serum aminotransferase elevations, but has yet to be linked to instances of acute...

A firmly established and well tolerated angiotensin-converting enzyme inhibitor. It attenuates the myocardial infarction induced rise in cardiac cytokine expression. Clinical trials show that quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele.

Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril (3 mg/kg) reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril (10-200...