283 products were found matching "K01283"!

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. ACE antibody detects Angiotensin I converting enzyme, a zinc-dependent peptidase that plays a pivotal role in blood pressure regulation and electrolyte balance. The UniProt recommended name is Angiotensin I converting enzyme (ACE). This...

Protein function: Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane...

Captopril is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 23 nM for the rabbit lung enzyme). It inhibits contractions in isolated guinea pig ileal segments induced by angiotensin I or bradykinin (IC50s = 23 and 3 nM, respectively) but not those induced by angiotensin II, histamine, acetylcholine,...

Zofenopril-d5 is intended for use as an internal standard for the quantification of zofenopril (Cay-29525) by GC- or LC-MS. Zofenopril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor zofenoprilat (Cay-38124). Zofenopril is hydrolyzed by cardiac esterases in vivo to form zofenoprilat. It...

Ramiprilat is the active metabolite of ramipril (Cay-15558) and functions as an angiotensin-converting enzyme inhibitor (pKi = 9.08 in human heart) to suppress the conversion of angiotensin I to angiotensin II and the degradation of bradykinin, thereby preventing vasoconstriction. Furthermore, ramiprilat is reported...

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM). It reduces the formation of endothelin-1 (Cay-24127) and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized...

Ramipril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor ramiprilat (Cay-15557). Ramipril (2.5 mg/kg per day, p.o.) reduces systolic blood pressure in spontaneously hypertensive rats. It reduces aortic valve backscatter and improves aortic flow in a rabbit model of aortic valve stenosis....

Enalapril is an inhibitor of angiotensin-converting enzyme (ACE, IC50 = 1.2 nM in porcine plasma). In vivo, enalapril (0.05-1 mg/kg, p.o.) inhibits pressor responses induced by angiotensin I (Cay-24737) in rats and dogs in a dose-dependent manner. Enalapril reduces heart rate, systolic and diastolic blood pressures,...

An antihypertensive agent known to reduce the incidence of vascular dementia and Alzheimer's disease. Found to have a potential for colon cancer prevention. (ACE inhibitor)

Fosinopril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril (2.5 mg/kg) reduces...

Enalaprilat is an active metabolite of the angiotensin-converting enzyme (ACE) inhibitor enalapril (Cay-16041).. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to...

Perindopril is an orally active angiotensin converting enzyme (ACE) inhibitor that effectively lowers blood pressure. It is a prodrug that is metabolized to perindoprilat (Cay-17574), a specific, competitive inhibitor of ACE (IC50 = 1.5-3.2 nM in vitro).Formal Name:...