PTUPB

PTUPB is a dual inhibitor of soluble epoxide hydrolase (sEH) and COX-2 (IC50s = 0.009 and 1.26 µM, respectively). It is selective for sEH and COX-2 over COX-1 (IC50 = >100 µM). PTUPB (10 mg/kg) increases latency to paw withdrawal in the von Frey mechanical assay in a rat model of LPS-induced inflammatory pain. It inhibits VEGF-induced angiogenesis in a Matrigel(TM) plug assay in mice, as well as reduces the number of metastases in a murine Lewis lung carcinoma model, when administered at a dose of 30 mg/kg per day. PTUPB reduces body and hepatic weights, as well as hepatic triglyceride and cholesterol levels and collagen deposition in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD).Formal Name: 4-[5-phenyl-3-[3-[[[[4-(trifluoromethyl)phenyl]amino]carbonyl]amino]propyl]-1H-pyrazol-1-yl]-benzenesulfonamide. CAS Number: 1287761-01-6. Molecular Formula: C26H24F3N5O3S. Formula Weight: 543.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.30 mg/ml, Ethanol: 1 mg/ml. lambdamax: 253 nm. SMILES: NS(C1=CC=C(N2N=C(CCCNC(NC3=CC=C(C(F)(F)F)C=C3)=O)C=C2C4=CC=CC=C4)C=C1)(=O)=O. InChi Code: InChI=1S/C26H24F3N5O3S/c27-26(28,29)19-8-10-20(11-9-19)32-25(35)31-16-4-7-21-17-24(18-5-2-1-3-6-18)34(33-21)22-12-14-23(15-13-22)38(30,36)37/h1-3,5-6,8-15,17H,4,7,16H2,(H2,30,36,37)(H2,31,32,35). InChi Key: CSEPEVFNTFMBAE-UHFFFAOYSA-N.