38 products were found matching "K08726"!

(±)13,14-DiHDoTrE is an oxylipin and a racemic mixture of the (R)/(S) enantiomeric forms biosynthesized from the adrenic acid metabolite (±)13,14-EDT (Cay-38937) by soluble epoxide hydrolase (sEH).Formal Name: 13,14-dihydroxy-7Z,10Z,16Z-docosatrienoic acid. CAS Number: 944908-94-5. Synonyms: (±)13,14-DHDT,...

Soluble epoxide hydrolase (sEH) converts epoxides to their corresponding diols. Inhibitors of sEH have anti-inflammatory, anti-hypertensive, neuroprotective, and cardioprotective effects. TPPU is a potent inhibitor of both human and mouse sEH (IC50 = 3.7 and 2.8 nM, respectively). The pharmacokinetics of this...

EpETrE metabolites of arachidonic acid such as 11(12-EpETrE and 14(15)-EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors...

(±)7(S),8(S)-DiHDoTrE is an oxylipin.Formal Name: 7S,8S-dihydroxy-10Z,13Z,16Z-docosatrienoic acid. Synonyms: (±)7(S),8(S)-DHDT. Molecular Formula: C22H38O4. Formula Weight: 366.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: 10 mg/ml, Ethanol: 10 mg/ml. SMILES:...

AR-9281 is an inhibitor of soluble epoxide hydrolase (sEH, IC50 = 7 nM for the human enzyme). It reduces LPS-induced increases in plasma levels of dihydroxyeicosatrienoic acids (DiHETs), prostaglandin E2 (PGE2, Cay-14010), and PGD2 (Cay-12010) in rats when administered at a dose of 3 mg/kg. AR-9281 (1 and 3 mg/kg)...

Soluble epoxide hydrolase (sEH) inhibitors have important therapeutic use by increasing the in vivo concentration of EETs and other fatty acid epoxides, resulting in anti-inflammatory, antihypertensive, neuroprotective, and cardioprotective effects. CAY10640 is a 1-aryl-3-(1-acylpiperidin-4-yl)urea analog that...

Soluble epoxide hydrolase (sEH) is a member of the alpha/beta-hydrolase fold enzyme family that catalyzes the hydrolysis of bioactive fatty acid epoxides to inactive vicinal diols. It is a homodimer in which each subunit is composed of two domains, a C-terminal epoxide hydrolase domain and an N-terminal phosphatase...

Soluble epoxide hydrolase (sEH) PROTAC 1a is a proteolysis-targeting chimera (PROTAC) that contains cereblon ligand 1 (Cay-21589) connected to the sEH inhibitor t-TUCB (Cay-36384) by a linker region. It drives sEH degradation and selectively inhibits the hydrolase activity of sEH (IC50 = 0.8 nM) over its phosphatase...

Epoxyeicosatrienoic acid (EpETrE, EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids...

Docosahexaenoic acid (DHA, Cay-90310) is the most abundant omega-3 fatty acid in neural tissues, especially in the brain and retina. (±)7(8)-EpDPA is an epoxide derivative of DHA that is generated by the action of cytochrome P450 epoxygenases. It is naturally occurring in plasma and brain and spinal cord tissues and...

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)13(14)-EpDPA is a docosahexaenoic acid (DHA, Cay-90310) epoxygenase metabolite, derived via epoxidation of the 13,14-double bond of DHA. It has been detected in rat brain and spinal cord and is a preferred...

Cytochrome P450 metabolism of polyunsaturated fatty acids produces numerous bioactive epoxide regioisomers. (±)10(11)-EpDPA is a docosahexaenoic acid (DHA, Cay-90310) epoxygenase metabolite, derived via epoxidation of the 10,11-double bond of DHA. It has been detected in rat brain and spinal cord, as well as human...