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PFI-1 is an inhibitor of BET bromodomains (BRDs) that prevents the association of BET with histones, it acts as an acyl-lysine (Kac) mimetic inhibitor, binding the Kac site of BRD2 and BRD4. PFI-1 exhibits anti-inflammatory and anticancer activities. In H202-treated bronchial epithelial cells, PFI-1 decreases expression of IL-6 and CXCL8. In leukemia cells, PFI-1 downregulates expression of Myc and AurKB, inducing G1 phase cell cycle arrest and suppressing cell growth.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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