3 products were found matching "1403764-72-6"!
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PFI-1
Item number: Cay11155-1
Bromodomains recognize acetylated lysine residues and recruit regulatory complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. The isolated individual or tandem bromodomains of bromodomain-containing protein (BRD) 2 and BRD4 bind acetylated histone tails, which couples...
| Keywords: | PF-06405761, 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide |
| Application: | Bromodomain inhibitor |
| CAS | 1403764-72-6 |
| MW: | 347.4 D |
From 52.00€
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MPI_5a
Item number: SYN-3040-M100
Solid. Soluble in DMSO. MPI_5a is a potent selective inhibitor of HDAC6. HDAC6 is a predominantly cytoplasmic enzyme that targets alpha-tubulin, cortactin and heat shock protein 90, and other substrates. MPI-5a has an IC50 of 36nM in tumour cell models and inhibits the acetylation of tubulin in cells with an IC50...
| Keywords: | MPI5a, N-Hydroxy-2-(1-methyl-1H-pyrrole-2-carbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide |
| Application: | HDAC6 inhibitor |
| CAS | 1403764-72-6 |
| MW: | 299,3 D |
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PFI-1
Item number: LKT-P2133.1
PFI-1 is an inhibitor of BET bromodomains (BRDs) that prevents the association of BET with histones, it acts as an acyl-lysine (Kac) mimetic inhibitor, binding the Kac site of BRD2 and BRD4. PFI-1 exhibits anti-inflammatory and anticancer activities. In H202-treated bronchial epithelial cells, PFI-1 decreases...
| Keywords: | PF-06405761 |
| Application: | Bromodomain inhibitor |
| CAS | 1403764-72-6 |
| MW: | 347.39 D |
From 95.00€
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