MT-802

MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (Cay-16274) linked to the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK degradation in primary X-linked agammaglobulinemia (XLA) cells expressing wild-type BTK or the ibrutinib-resistant mutant BTKC481S. It also induces BTK degradation in patient-derived chronic lymphocytic leukemia (CLL) cells.Formal Name: 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1, 3-dioxo-1H-isoindol-5-yl]-acetamide. CAS Number: 2231744-29-7. Molecular Formula: C41H41N9O8. Formula Weight: 787.8. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly Soluble, DMSO: Soluble, Methanol: Slightly Soluble. SMILES: O=C1C2=CC=C(NC(COCCOCCN3CCC(CC3)N4N=C(C5=C4N=CN=C5N)C6=CC=C(OC7=CC=CC=C7)C=C6)=O)C=C2C(N1C8C(NC(CC8)=O)=O)=O. InChi Code: InChI=1S/C41H41N9O8/c42-37-35-36(25-6-9-29(10-7-25)58-28-4-2-1-3-5-28)47-50(38(35)44-24-43-37)27-14-16-48(17-15-27)18-19-56-20-21-57-23-34(52)45-26-8-11-30-31(22-26)41(55)49(40(30)54)32-12-13-33(51)46-39(32)53/h1-11,22,24,27,32H,12-21,23H2,(H,45,52)(H2,42,43,44)(H,46,51,53). InChi Key: AJTLGUJXIKEZCQ-UHFFFAOYSA-N.