129 products were found matching "K07370"!

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ARQ 531
ARQ 531

Item number: Cay30165-1

ARQ 531 is an inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 0.85 nM). It reduces the viability of, and inhibits BTK autophosphorylation in, OCI-AML-2 acute myeloid leukemia (AML) cells when used at concentrations of 0.3 and 1 µM. In vivo, ARQ 531 (75 mg/kg) reduces tumor growth in an SU-DHL-4 B cell lymphoma...
Keywords: MK-1026, Nemtabrutinib,...
Application: BTK inhibitor
CAS 2095393-15-8
MW: 478.9 D
From 34.00€ *
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MT-802
MT-802

Item number: Cay36581-25

MT-802 is a proteolysis-targeting chimera (PROTAC) composed of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib (Cay-16274) linked to the cereblon inhibitor pomalidomide (Cay-19877). It induces degradation of BTK in NAMALWA cells when used at concentrations ranging from 10 to 250 nM. MT-802 (1 µM) induces BTK...
Keywords: 2-[2-[2-[4-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]ethoxy]ethoxy]-N-[2-(2,6-dioxo-3-p...
Application: BTK degradation driving PROTAC
CAS 2231744-29-7
MW: 787.8 D
From 57.00€ *
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Human Btk (Bruton'S Tyrosine Kinase) ELISA Kit
Human Btk (Bruton'S Tyrosine Kinase) ELISA Kit

Item number: ELK-ELK2680.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human Btk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human Btk. Next,...
Keywords: BPK, BTK, ATK, AGMX1, Bruton tyrosine kinase, B-cell progenitor kinase, Tyrosine-protein kinase BTK, Agammaglobulinemia...
Application: ELISA
Species reactivity: human
365.00€ * From 328.50€ *
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Mouse Btk (Bruton'S Tyrosine Kinase) ELISA Kit
Mouse Btk (Bruton'S Tyrosine Kinase) ELISA Kit

Item number: ELK-ELK5122.48

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse Btk. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse Btk. Next,...
Keywords: BPK, Bpk, ATK, Btk, Kinase EMB, EC=2.7.10.2, Bruton tyrosine kinase, B-cell progenitor kinase, Tyrosine-protein kinase...
Application: ELISA
Species reactivity: mouse
365.00€ * From 328.50€ *
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Ibrutinib
Ibrutinib

Item number: Cay16274-1

Bruton's tyrosine kinase (BTK) is a member of the BTK/Tec family of protein tyrosine kinases involved in signal transduction pathways regulating proliferation, survival, migration, and tissue homing of B-cells. Ibrutinib is an irreversible inhibitor of BTK (IC50 = 0.5 nM) that selectively blocks B cell activation,...
Keywords: Imbruvica, PCI 32765, 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one
Application: BTK inhibitor
CAS 936563-96-1
MW: 440.5 D
From 50.00€ *
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Tolebrutinib
Tolebrutinib

Item number: Cay37723-10

Tolebrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK, IC50 = 1 nM). It decreases the number of CD69+ B cells in isolated mouse whole blood (IC50 = 200 nM).Formal Name: 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one. CAS...
Keywords: 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)-2H-imidazo[4,5-c]pyridin-2-one
Application: Irreversible BTK inhibitor
CAS 1971920-73-6
MW: 455.5 D
From 90.00€ *
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Anti-BTK
Anti-BTK

Item number: NSJ-F52632-0.08ML

In 1X PBS, pH 7.4, with 0.09% sodium azide. Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma...
Keywords: Anti-BPK, Anti-ATK, Anti-BTK, Anti-AGMX1, EC=2.7.10.2, Anti-Bruton tyrosine kinase, Anti-B-cell progenitor kinase,...
Application: WB, ELISA
Host: Rabbit
Species reactivity: human, mouse
From 326.00€ *
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PCI-32765
PCI-32765

Item number: LKT-P0932.1

PCI-32765 is an irreversible inhibitor of Bruton's tyrosine kinase (BTK), an enzyme that plays a significant role in B-cell receptor signaling and B-cell malignancies and autoimmune diseases such as x-linked agammaglobulinemia, chronic lymphocytic leukemia, and non-Hodgkin's lymphoma. PCI-32765's inhibition of BTK...
Keywords: Ibrutinib
Application: Bruton's tyrosine kinase inhibitor
CAS 936563-96-1
MW: 440.5 D
From 99.00€ *
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AVL-292
AVL-292

Item number: LKT-A8644.25

AVL-292 is a Bruton's tyrosine kinase (BTK) inhibitor that exhibits anticancer chemotherapeutic activities. AVL-292 is in clinical development as a potential treatment for B-cell-related disorders such as chronic lymphocytic leukemia (CLL).
Keywords: CC-292
Application: BTK inhibitor
CAS 1202757-89-8
MW: 423.44 D
From 90.00€ *
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Ibrutinib
Ibrutinib

Item number: AG-CR1-3620-M025

White solid. Soluble in DMSO. Slightly soluble in ethanol (1mg/ml). Insoluble in water. Potent and highly selective Bruton's tyrosine kinase (BTK) inhibitor. Orally bioavailable and irreversible inhibitor of BTK (IC50 = 0.5 nM) with antineoplastic activity, Binds to and irreversibly inhibits BTK activity, preventing...
Keywords: PCI-32765
Application: BTK inhibitor
CAS 936563-96-1
MW: 440,5 D
88.00€ * From 79.20€ *
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ONO-4059 analog
ONO-4059 analog

Item number: Cay18924-1

ONO-4059 analog is a derivative of the Bruton's tyrosine kinase (BTK) inhibitor ONO-4059 (Cay-32957).Formal Name: 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one. CAS Number: 1351635-67-0. Synonyms: GS-4059 analog. Molecular Formula: C25H24N6O3. Formula Weight:...
Keywords: GS-4059 analog, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one
Application: BTK inhibitor
CAS 1351635-67-0
MW: 456.5 D
From 60.00€ *
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HM61713
HM61713

Item number: Cay19481-1

HM61713 is an inhibitor of mutant EGFR (IC50 = 0.01 µM for EGFRT790M/L858R). It is selective for EGFRT790M/L858R over PI3Kalpha (IC50 = >10 µM). HM61713 is cytotoxic to A549, H1975, and H460 lung and MCF-7 breast cancer cells (IC50s = 4.29, 0.52, 5.29, and 26.9 µM, respectively). It reduces tumor growth in an...
Keywords: BI-1482694, Olmutinib,...
Application: BTK inhibitor
CAS 1353550-13-6
MW: 486.6 D
From 43.00€ *
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