LY2109761

LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.Formal Name: 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline. CAS Number: 700874-71-1. Molecular Formula: C26H27N5O2. Formula Weight: 441.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 0.1 mg/ml, Ethanol: 2 mg/ml. lambdamax: 236 nm. SMILES: C12=NC=CC(C3=C(CCC4)N4N=C3C5=CC=CC=N5)=C1C=CC(OCCN6CCOCC6)=C2. InChi Code: InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2. InChi Key: IHLVSLOZUHKNMQ-UHFFFAOYSA-N.