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Item number: TGM-T2123-100mg

Description: LY2109761 is a novel selective TGF-beta receptor type I/II (TbetaRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively, shown to negatively affect the phosphorylation of Smad2. Target: Autophagy, TGF-beta/Smad. Smiles: C(CN1CCOCC1)Oc1ccc2c(ccnc2c1)-c1c2CCCn2nc1-c1ccccn1. References: Melisi D,...

CAS	700874-71-1
MW:	441.52 D

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LY2109761

Item number: Cay15409-1

LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1/type II kinases (IC50 = 69 nM). It has been used to study the role of TGF-beta signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 µM of the compound completely disrupts Smad-2 phosphorylation, an immediate...

Keywords:	4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-[2-(4-morpholinyl)ethoxy]-quinoline
Application:	TGFBR1/2 inhibitor
CAS	700874-71-1
MW:	441.5 D

From 61.00€ *

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