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KDM4D-IN-1 is an inhibitor of the histone demethylase jumonji domain-containing 2D (JMJD2D, IC50 = 0.41 µM). It is selective for JMJD2D over JMJD1B, JMJD2B, and jumonji AT rich interactive domain-containing protein 1A (JARID1A, IC50s = >10 µM for all). KDM4D-IN-1 (0.5 µM) decreases the colony formation, migration, and invasion of Caki-1 clear cell renal carcinoma cells and 786-O adenocarcinoma cells. It reduces tumor growth and vessel development in a 786-O mouse xenograft model.Formal Name: 4,5-dihydro-2-methyl-5-oxo-pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine-3-carbonitrile. CAS Number: 2098902-68-0. Synonyms: KDM4D Inhibitor 1. Molecular Formula: C11H7N5O. Formula Weight: 225.2. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 0.2 mg/ml, DMSO: 0.2 mg/ml. lambdamax: 222, 259 nm. SMILES: N#CC(C(C)=NN1C2=NC=CC=C23)=C1NC3=O. InChi Code: InChI=1S/C11H7N5O/c1-6-8(5-12)10-14-11(17)7-3-2-4-13-9(7)16(10)15-6/h2-4H,1H3,(H,14,17). InChi Key: FIRSAIIBSBCBTF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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