ITI214

ITI214 is an inhibitor of phosphodiesterase 1 (PDE1, Ki = 0.058 nM). It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when administered at a dose of 50 mg/kg. ITI214 (0.1, 3, and 10 mg/kg) reverses MK-801-induced decreases in spontaneous alteration in the T-maze continuous alternation task in mice.Formal Name: (6aR,9aS)-2-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, monophosphate. CAS Number: 1642303-38-5. Molecular Formula: C29H26FN7O . H3PO4. Formula Weight: 605.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: CN1C2=N[C@@]3([H])[C@@](CCC3)([H])N2C4=NN(CC5=CC=C(C6=NC(F)=CC=C6)C=C5)C(NC7=CC=CC=C7)=C4C1=O.O=P(O)(O)O. InChi Code: InChI=1S/C29H26FN7O.H3O4P/c1-35-28(38)25-26(31-20-7-3-2-4-8-20)36(34-27(25)37-23-11-5-10-22(23)33-29(35)37)17-18-13-15-19(16-14-18)21-9-6-12-24(30)32-21,1-5(2,3)4/h2-4,6-9,12-16,22-23,31H,5,10-11,17H2,1H3,(H3,1,2,3,4)/t22-,23+,/m1./s1. InChi Key: ZPIAAFIYOPWWJL-RFPXDPOKSA-N.