112 products were found matching "K13755"!

Rabbit Polyclonal PDE1C Antibody against Human phosphodiesterase 1C. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000004347: 76%, ENSRNOG00000012337:...

Active human PDE1B (GenBank Accession No. NM_000924), full length with N-terminal GST tag, MW= 87 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

Phosphodiesterases (PDEs) play an important role in dynamic regulation of cAMP and cGMP signaling. PDE1A1 is a calmodulin-dependent PDE and expressed in lung and heart. PDE1A1 is believed to regulate vascular smooth muscle contraction and may play a role in sperm function. The PDE1A Assay Kit is designed for...

The PDE1B Assay Kit is designed for identification of PDE1B inhibitors using fluorescence polarization. The assay is based on the binding of a fluorescent nucleotide monophosphate generated by PDE1B to the binding agent. PDE1B is a calcium-dependent cyclic nucleotide phosphodiesterase that is highly expressed in the...

Vinpocetine is a semisynthetic alkaloid commonly used as an inhibitor of phosphodiesterase 1 (PDE1), blocking the hydrolysis of both cAMP and cGMP (Ki = 14 µM). In addition to its use as a selective PDE1 inhibitor in basic research, vinpocetine has diverse cerebral and neurological effects in vivo. Vinpocetine also...

Calmodulin antagonist, Cell proliferation inhibitor, Ca2????regulated phosphodiesterase (PDE I) inhibitor, Myosin light chain kinase (MLCK) inhibitor.

ITI214 is an inhibitor of phosphodiesterase 1 (PDE1, Ki = 0.058 nM). It is selective for PDE1 over PDE2A, -3B, -4A, -5A, -6, -7B, -8A, -9A, -10A, and -11A (Kis = 0.16-18 µM). ITI214 (3 and 6 mg/kg) enhances novel object recognition in rats. It increases prefrontal cortex cAMP and cGMP levels in mice when...

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. [The UniProt Consortium]

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate. [The UniProt Consortium]

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a high affinity for both cAMP and cGMP. [The UniProt Consortium]

Protein function: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher affinity for cGMP than for cAMP. [The UniProt Consortium]

Rat PDE1B (GenBank Accession No. NM_022710), full length with N-terminal HIS-GST tag, MW= 89kDa, expressed in a Baculovirus infected Sf9 cell expression system.