IMR-1A

IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and CFB1, suppressor of Hairless, Lag-1 (CSL) transcription factor. IMR-1A increases multiciliation in primary choroid plexus cancer cells when used at a concentration of 25 µM.Formal Name: 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid. CAS Number: 331862-41-0. Molecular Formula: C13H11NO5S2. Formula Weight: 325.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml. lambdamax: 393 nm. SMILES: O=C(COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC)O. InChi Code: InChI=1S/C13H11NO5S2/c1-18-9-4-7(2-3-8(9)19-6-11(15)16)5-10-12(17)14-13(20)21-10/h2-5H,6H2,1H3,(H,15,16)(H,14,17,20). InChi Key: DVBJNSKWHSGTDK-UHFFFAOYSA-N.