17 products were found matching "K20996"!

IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and...

FLI-06 is a first-of-its-kind inhibitor of Notch signaling (EC50 = 2.3 µM) that acts upstream of alpha-secretase and beta-secretase cleavage. It disrupts the intracellular trafficking and processing of the Notch signaling pathway, inhibiting general secretion at a stage before exit from the endoplasmic reticulum...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. NOTCH4 is a member of the Notch family. In situ hybridization revealed that Notch4 transcripts are primarily restricted to endothelial cells in embryonic and adult life, suggesting a specific role for the protein during development of vertebrate endothelium. The...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates...

This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain...

Protein function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of...

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch...

notch 4(NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of...

notch 4(NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of...

Notch4 is a 250kD member of the NOTCH family of proteins. It is primarily expressed on endothelium. Human Notch4 is a 1980aa type I transmembrane (TM) glycoprotein that contains a 1424 aa extracellular domain (ECD) and a 535aa cytoplasmic region. Notch4 undergoes proteolytic processing at multiple sites. There is...