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IMR-1A
Item number: Cay37432-10
IMR-1A is an inhibitor of Notch ternary complex formation (IC50 = 0.5 µM) and an active metabolite of the mastermind-like 1 (MAM-1) chromatin recruitment inhibitor IMR-1 (Cay-27920). It binds to the intracellular domain of Notch (Kd = 2.9 µM) and disrupts the protein-protein interactions between Notch and MAM-1 and...
| Keywords: | 2-[2-methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl],phenoxy]-acetic acid |
| Application: | Notch ternary complex formation inhibitor |
| CAS | 331862-41-0 |
| MW: | 325.4 D |
From 92.00€
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IMR-1A
Item number: TGM-T3540-100mg
Description: IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 µMol/L. Target: Gamma-secretase, Drug Metabolite. Smiles: COc1cc(\C=C2\SC(=S)NC2=O)ccc1OCC(O)=O
| Application: | Notch ternary complex formation inhibitor |
| CAS | 331862-41-0 |
| MW: | 325.36 D |
From 42.00€
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