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HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs, IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively). It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in bone marrow-derived macrophages. SIK inhibitors, including HG-9-91-01, enhance CREB-dependent gene transcription and IL-10 production in bone marrow-derived dendritic cells, THP-1 cells, and human primary macrophages.Formal Name: N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-urea. CAS Number: 1456858-58-4. Molecular Formula: C32H37N7O3. Formula Weight: 567.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 3 mg/ml, Ethanol: 5 mg/ml, Ethanol:PBS(pH 7.2) (1:1): 0.5 mg. lambdamax: 303 nm. SMILES: CC1=C(NC(N(C2=C(OC)C=C(OC)C=C2)C3=NC=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=C3)=O)C(C)=CC=C1. InChi Code: InChI=1S/C32H37N7O3/c1-22-7-6-8-23(2)31(22)36-32(40)39(27-14-13-26(41-4)19-28(27)42-5)30-20-29(33-21-34-30)35-24-9-11-25(12-10-24)38-17-15-37(3)16-18-38/h6-14,19-21H,15-18H2,1-5H3,(H,36,40)(H,33,34,35). InChi Key: UYUHRKLITDJEHB-UHFFFAOYSA-N.
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