28 products were found matching "K16311"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human SIK2. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human SIK2. Next,...

The Chemi-Verse(TM) SIK2 Kinase Assay Kit is designed to measure SIK2 (salt inducible kinase 2) kinase activity for screening and profiling applications using ADP-Glo(TM) as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant SIK2 kinase, kinase substrate, ATP,...

HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs, IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively). It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in...

Protein function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [The UniProt Consortium]

Protein function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [The UniProt Consortium]

Recombinant human QIK, full length, with N-terminal GST-tag, expressed in Sf9 insect cells via a baculovirus expression system.

Protein function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [The UniProt Consortium]

ARN3236 is an inhibitor of salt-inducible kinase 2 (SIK2, IC50 = 50s = 21.63 and 6.63 nM, respectively). It inhibits TNF-alpha secretion in RAW 264.7 cells (IC50 = ~2.5 µM) and reduces phosphorylation of the SIK2 targets CRTC3 and HDAC4 in macrophages when used at a concentration of 3 µM. ARN3236 inhibits growth of...

Protein function: Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2)....

YKL-05-099 is an inhibitor of salt-inducible kinase 2 (SIK2, IC50 = 0.04 µM for the human enzyme). It is selective for SIK2 over a panel of 141 kinases at 1 µM but also inhibits 14 other kinases, including SIK3, Ephrin receptors, and Src. YKL-05-099 increases IL-10 production in zymosan A-induced isolated mouse bone...