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HG-9-91-01
Item number: TGM-T4599-100mg
Description: HG-9-91-01 (SIK inhibitor 1) is a potent and highly selective salt-inducible kinase (SIKs) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3respectively. Target: SIK. Smiles: COc1ccc(N(C(=O)Nc2c(C)cccc2C)c2cc(Nc3ccc(cc3)N3CCN(C)CC3)ncn2)c(OC)c1. References: Clark K, et al....
| Keywords: | SIK inhibitor 1 |
| Application: | Salt-inducible kinase inhibitor |
| CAS | 1456858-58-4 |
| MW: | 567.68 D |
From 75.00€
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HG-9-91-01
Item number: Cay19179-1
HG-9-91-01 is an inhibitor of salt-inducible kinases (SIKs, IC50s = 0.92, 6.6, and 9.6 nM for SIK1, SIK2, and SIK3, respectively). It also inhibits Src, Lck, Yes, and BTK, as well as FGF and Ephrin receptors. HG-9-91-01 increases LPS-stimulated IL-10 production and suppresses pro-inflammatory cytokine secretion in...
| Keywords: | N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-urea |
| Application: | Salt-inducible kinase inhibitor |
| CAS | 1456858-58-4 |
| MW: | 567.7 D |
From 90.00€
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