GW 803430

GW 803430 is an antagonist of melanin-concentrating hormone receptor 1 (MCH1, IC50 = 0.5 nM). It reduces cumulative body weight and food intake in diet-induced obese rats when administered at doses of 1 and 3 mg/kg. GW 803430 (10 and 30 mg/kg) decreases marble-burying behavior in mice, indicating anxiolytic activity, but does not affect performance in the rotorod test. It also reduces immobility time in the forced swim and tail suspension tests in mice at doses of 3 and 10 mg/kg, respectively, indicating antidepressant-like activity.Formal Name: 6-(4-chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. CAS Number: 515141-51-2. Synonyms: GW 3430. Molecular Formula: C25H24ClN3O3S. Formula Weight: 482.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): Slightly soluble. lambdamax: 228, 264, 312 nm. SMILES: O=C1C2=C(C=C(C3=CC=C(Cl)C=C3)S2)N=CN1C4=CC(OC)=C(OCCN5CCCC5)C=C4. InChi Code: InChI=1S/C25H24ClN3O3S/c1-31-22-14-19(8-9-21(22)32-13-12-28-10-2-3-11-28)29-16-27-20-15-23(33-24(20)25(29)30)17-4-6-18(26)7-5-17/h4-9,14-16H,2-3,10-13H2,1H3. InChi Key: MWULMTACIBZPGN-UHFFFAOYSA-N.