GSK0660

GSK0660 is the first reported antagonist of PPARbeta/delta (IC50 = 155 nM) with no measurable affinity for PPARalpha or PPARgamma (IC50s > 10 µM). Because of the limited bioavailability of GSK0660, the related compound GSK3787 (Cay-15219) was developed as a selective PPARbeta/delta antagonist with more suitable pharmacokinetic properties.Formal Name: 3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid, methyl ester. CAS Number: 1014691-61-2. Molecular Formula: C19H18N2O5S2. Formula Weight: 418.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml, DMSO: 12 mg/ml, Ethanol: 2 mg/ml. lambdamax: 286 nm. SMILES: O=S(NC(C=C1)=C(OC)C=C1NC2=CC=CC=C2)(C3=C(C(OC)=O)SC=C3)=O. InChi Code: InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3. InChi Key: NDFKBGWLUHKMFY-UHFFFAOYSA-N.