82 products were found matching "K04504"!

The transcription factor peroxisome proliferator-activated receptor delta (PPARdelta) is a member of the superfamily of nuclear hormone receptors and is implicated both in lipid metabolism and in the regulation of genes with potential roles in neurotoxicity. GW 0742 is a selective PPARdelta agonist (EC50 = 1.1 nM)...

PPARbeta/delta is thought to play a role in lipid homeostasis and glucose disposal by regulating genes involved in fatty acid oxidation, reverse cholesterol transport, and carbon substrate utilization in skeletal muscle. It has also been implicated in the progression of certain cancers. GSK3787 is an irreversible...

White to off-white solid. Soluble in DMSO (30mg/ml), dimethylformamide (30mg/ml), ethanol (10mg/ml) or methanol (30mg/ml). Sparingly soluble in water. Potent and selective peroxisome proliferator-activated receptor (PPAR) delta agonist/activator with high affinity (Ki=1nM) and potency (EC50=1nM) for PPARdelta and...

L-165,041 is a potent and selective agonist of the nuclear receptor PPARbeta/delta (Ki = 9 nM, EC50 = ~500 nM for hPPARbeta/delta). It is less effective against PPARalpha and PPARgamma, with activity at those receptors depending on cell type and system of study. L-165,041 is used to evaluate the diverse roles of...

Peroxisome proliferator-activated receptor delta (PPARdelta) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW 501516 is the first highly selective synthetic PPARdelta agonist available. GW 501516 binds to human PPARdelta...

PPARdelta is one of three peroxisome proliferator-activated receptor (PPAR) subtypes that possess a domain structure common to other members of the nuclear receptor gene family. It was first cloned from Xenopus laevis and named PPARbeta. PPARdelta is ubiquitously expressed but is particularly abundant in tissues...

GSK0660 is the first reported antagonist of PPARbeta/delta (IC50 = 155 nM) with no measurable affinity for PPARalpha or PPARgamma (IC50s > 10 µM). Because of the limited bioavailability of GSK0660, the related compound GSK3787 (Cay-15219) was developed as a selective PPARbeta/delta antagonist with more suitable...

This nuclear receptor assay system utilizes proprietary non-human cells engineered to provide constitutive, high-level expression of the human peroxisome proliferator-activated receptor delta (NR1C2), a ligand-dependent transcription factor commonly referred to as PPARD or PPARdelta. INDIGO's reporter cells include...

DG-172 is an orally available inverse agonist of PPARbeta/delta (IC50 = 27 nM), down-regulating transcription of ANGPTL4 in mouse myoblasts (IC50 = 9.5 nM). It alters the differentiation of bone marrow cells, augmenting GM-CSF-induced development into subsets of mature and immature dendritic cells. Inverse agonists...

MBX-8025 is an agonist of peroxisome proliferator-activated receptor delta (PPARdelta). It is greater than 750- and 2,500-fold selective for PPARdelta over PPARalpha and PPARgamma. MBX-8025 (10 mg/kg per day for eight weeks) reduces increases in fasting blood glucose and serum insulin levels, and decreases insulin...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the large family of nuclear hormone receptors. There are three subtypes, PPARalpha, beta/delta, and gamma, which are expressed at variable levels in different tissues. Cayman's PPARdelta Transcription Factor...

Elafibranor is an agonist of the peroxisome proliferator-activated receptors (PPAR) alpha and delta. It increases HDL secretion and expression of the lipid-related genes ABCA1, PLIN2, and ABHD5 in Caco-2/TC7 cells in a PPARalpha-dependent manner. Elafibranor (10 mg/kg) decreases levels of plasma triglycerides and...