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Product information "FK-506 (Fujimycin, Tacrolimus)"
FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein-12 (FKBP12). The resulting complex, in turn, interferes with calcineurin substrate interaction. Synonyms: Advagraf, FR 900506, Fujimycin, L 679934, Prograf, Protopic, TacroBell, Tacrolimus, Tsukubaenolide, CAS Number: 104987-11-3, Molecular Formula: C44H69NO12, Molecular Weight: 804.02, Appearance: Supplied as a white powder. Purity: >99% (HPLC, TLC), Melting Point: 128-132°C, Elemental Analysis: Calculated:, C: 65.73%, H: 8.65%, N: 1.75%, Solubility: Soluble in DMSO at 100mg/ml, soluble in ethanol at 100mg/ml, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
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