FK-506
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Potent immunosuppressant (as cyclosporin A and rapamycin). Suppresses proliferation of cytotoxic... more
Product information "FK-506"
Potent immunosuppressant (as cyclosporin A and rapamycin). Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2). Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B, calcineurin), leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis). Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2 release compound. NF-kappaB suppressor by induction of unfolded protein response (UPR). Anti-cancer compound. Apoptosis inducer.
| Keywords: | Tacrolimus, Fujimycin |
| Supplier: | AdipoGen Life Sciences |
| Supplier-Nr: | AG-CN2-0047 |
Properties
| Application: | Immunosuppressant |
| Host: | Streptomyces FCZ0311 |
| Formula: | C44H69NO12-H2O |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 104987-11-3| Matching products |
| KEGG ID : | K09568 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: +20°C) |
| Signal Word: | Danger |
| GHS Hazard Pictograms: |
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| H Phrases: | H301 |
| P Phrases: | P264, P301+P310 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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