FB23-2

FB23-2 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM). It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases m6A levels in isolated human bone marrow cells, as well as suppresses the proliferation of isolated human bone marrow cells and a panel of acute myeloid leukemia (AML) cells (IC50s = 1.9-5.2 µM). In vivo, FB23-2 (2 mg/kg) delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model.Formal Name: 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-benzamide. CAS Number: 2243736-45-8. Molecular Formula: C18H15Cl2N3O3. Formula Weight: 392.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: Slightly soluble, DMSO: Slightly soluble, Methanol: Slightly soluble. lambdamax: 216 nm. SMILES: O=C(C1=C(NC2=C(C=C(C3=C(C)ON=C3C)C=C2Cl)Cl)C=CC=C1)NO. InChi Code: InChI=1S/C18H15Cl2N3O3/c1-9-16(10(2)26-23-9)11-7-13(19)17(14(20)8-11)21-15-6-4-3-5-12(15)18(24)22-25/h3-8,21,25H,1-2H3,(H,22,24). InChi Key: ILHNIWOZZKIBNW-UHFFFAOYSA-N.