51 products were found matching "K19469"!

FB23 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 0.06 µM) and an active metabolite of FB23-2 (Cay-36606). It reduces the proliferation of NB4 and Mono-Mac-6 acute myeloid leukemia (AML) cells (IC50s = 44.8 and 23.6 µM, respectively).Formal...

The FTO Chemiluminescent Assay Kit is designed to measure FTO activity for screening and profiling applications. The key to the FTO Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to the activity. With this kit, only three simple steps on a...

Potent FTO (fat mass and obesity-associated gene) inhibitor for in vivo studies. FTO belongs to the Fe2+ and alpha-ketoglutarate (alpha-KG)-dependent oxygenase family. It demethylates N6-adenosine-modified (m6A) sites and N6,2'-O-dimethyladenosine-modified (m6Am) sites of mRNA. With its demethylase activity, FTO...

FB23-2 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM). It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases m6A levels in isolated human bone marrow cells, as well as...

Recognizes human FTO. Detects a band of about 59kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype and type 2 diabetes has been...

Recognizes mouse FTO. Detects a band of about 58kDa by Western blot. Weakly cross-reacts with human FTO. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype...

Protein function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or...

Human FTO, also known as Fat mass and obesity-associated protein, ALKBH9, BMIQ14, GDFD, KIAA1752, and alpha-ketoglutarate-dependent dioxygenase, GenBank Accession No. NM_001080432, a.a 32-505 (end), with N-terminal His-Tag and expressed in a E. coli cell expression system. MW = 56 kDa.

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...

Anti-FTO antibody is directed against human Fat mass and Obesity Related Protein. Anti-Fat mass and Obesity Related Protein is a Protein G purified antibody. Reactivity is expected with the following species based on 100% sequence homology: bovine, canine, horse, non-human primate, sheep. Protein function:...