68 products were found matching "K19469"!

N6-2'-O-Dimethyladenosine (m6Am) is a modified nucleoside, a substrate of the demethylase fat mass and obesity-associated protein (FTO), and an mRNA cap modification that increases mRNA stability. It is present on specific transcripts, including fatty acid binding protein 2 (Fabp2) and Fabp5, in an obesity-dependent...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. FTO antibody targets Fat mass and obesity associated protein (FTO), a nuclear protein that functions as an RNA demethylase and plays an important role in post-transcriptional regulation of gene...

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans...

Potent FTO (fat mass and obesity-associated gene) inhibitor for in vivo studies. FTO belongs to the Fe2+ and alpha-ketoglutarate (alpha-KG)-dependent oxygenase family. It demethylates N6-adenosine-modified (m6A) sites and N6,2'-O-dimethyladenosine-modified (m6Am) sites of mRNA. With its demethylase activity, FTO...

The FTO Chemiluminescent Assay Kit is designed to measure FTO activity for screening and profiling applications. The key to the FTO Chemiluminescent Assay Kit is a highly specific antibody that recognizes methylated substrate. Signal is inversely related to the activity. With this kit, only three simple steps on a...

Recognizes human FTO. Detects a band of about 59kDa by Western blot. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype and type 2 diabetes has been...

Recognizes mouse FTO. Detects a band of about 58kDa by Western blot. Weakly cross-reacts with human FTO. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes'mutation. An association between FTO genotype...

Protein function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single- stranded RNA containing 3-methyluracil, followed by single- stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or...

Human FTO, also known as Fat mass and obesity-associated protein, ALKBH9, BMIQ14, GDFD, KIAA1752, and alpha-ketoglutarate-dependent dioxygenase, GenBank Accession No. NM_001080432, a.a 32-505 (end), with N-terminal His-Tag and expressed in a E. coli cell expression system. MW = 56 kDa.

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...

Fat mass and obesity-associated (FTO) protein is a nuclear-residing N6-methyladenosine (m6A) RNA demethylase that is encoded by the FTO gene in humans. It is composed of an N-terminal domain similar in structure to members of the AlkB non-heme iron-containing dioxygenase family and a C-terminal domain that is not...