Eniluracil

Eniluracil is an irreversible inhibitor of dihydropyrimidine dehydrogenase (DPD, Ki = 1.6 µM), the rate-determining enzyme in the catabolism of pyrimidines, including 5-fluorouracil (Cay-14416). It inhibits liver DPD and elevates plasma pyrimidine levels in rats (ED50s = 1.8 and 10 µg/kg, respectively). Eniluracil (2 mg/kg) potentiates the antitumor effects of 5-fluorouracil in MC-38 murine colon carcinoma and MOPC 315 murine myeloma models.Formal Name: 5-ethynyl-2,4(1H,3H)-pyrimidinedione. CAS Number: 59989-18-3. Synonyms: 776C85, 5-Ethynyluracil, NSC 687296. Molecular Formula: C6H4N2O2. Formula Weight: 136.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml. lambdamax: 225, 285 nm. SMILES: O=C1NC=C(C(N1)=O)C#C. InChi Code: InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10). InChi Key: JOZGNYDSEBIJDH-UHFFFAOYSA-N.