9c(i472)

9c(i472) is an inhibitor of 15-lipoxygenase-1 (15-LO-1, IC50 = 0.19 µM). It decreases LPS- and IFN-gamma-induced NF-?B activity in RAW-Blue(TM) cells when used at concentrations of 0.2, 1, and 5 µM. 9c(i472) reduces LPS- and IFN-gamma-induced increases in Nos2 expression and lipid peroxidation in RAW 264.7 cells when used at a concentration of 5 µM.Formal Name: 6-chloro-3-[(1E)-3-[[(2-methoxyphenyl)methyl]amino]-3-oxo-1-propen-1-yl]-1H-indole-2-carboxylic acid, ethyl ester. CAS Number: 2349374-37-2. Synonyms: 15-LOX-1 Inhibitor i472. Molecular Formula: C22H21ClN2O4. Formula Weight: 412.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble, Methanol: slightly soluble. lambdamax: 221, 240, 283, 328 nm. SMILES: ClC1=CC=C2C(NC(C(OCC)=O)=C2/C=C/C(NCC3=CC=CC=C3OC)=O)=C1. InChi Code: InChI=1S/C22H21ClN2O4/c1-3-29-22(27)21-17(16-9-8-15(23)12-18(16)25-21)10-11-20(26)24-13-14-6-4-5-7-19(14)28-2/h4-12,25H,3,13H2,1-2H3,(H,24,26)/b11-10+. InChi Key: BRMZRDPEXXAZRV-ZHACJKMWSA-N.