44 products were found matching "K00460"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ALOX15. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ALOX15....

ThioLox is an inhibitor of 15-lipoxygenase 1 (15-LO-1, Ki = 3.3 µM). It also is an inhibitor of P. falciparum aspartate carbamoyltransferase (IC50 = 3.32 µM). ThioLox (50 µM) reduces LPS-induced expression of the mRNAs encoding TNF-alpha, inducible nitric oxide synthase (iNos), Il-1beta, Il-6, Il-8, and Il-12b in...

Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Cay-10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being...

Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves. Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM. Luteolin has also been found to inhibit the release of TNFalpha from neutrophils, and to inhibit...

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides. The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer. ML-351 is an inhibitor of human...

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid beta protein aggregate formation without changing total...

Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) by 15-lipoxygenase (15-LO) via 15(S)-HpEPE (Cay-42710) and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human...

NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A-23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM. The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.Formal...

Yellow solid. Soluble in DMSO, DMF, methanol or ethanol. Slightly soluble in water. Anticancer and antimetastatic, alpha-Glucosidase inhibitor, Topoisomerase I Inhibitor, Apoptosis inducer, Anti-inflammatory, 15-Lipoxygenase (15-LOX) inhibitor, IL-6 production inhibitor, Fatty acid synthase (FAS) inhibitor,...

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1, IC50 = 32 nM in a cell-free enzyme assay). It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over...

ALOX-15, also known as 15LOX-1, omega-6 lipoxygenase, or arachidonate 15-lipoxygenase (GenBank Accession No. NM_001140), a.a. 2- 662(end), with N-terminal FLAG-tag, MW=75 kDa, expressed in Sf9 insect cells via a baculovirus expression system.

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (Cay-10011298) at the sn-1 position and 15(S)-HpETE (Cay-44720) at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE, Cay-25871) by 15-lipoxygenase (15-LO)....