63 products were found matching "K00460"!

This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to...

Resolvin D1-d5 (RvD1-d5) is intended for use as an internal standard for the quantification of RvD1 (Cay-10012554) by GC- or LC-mass spectrometry. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA, Cay-90110) and docosahexaenoic acid (DHA, Cay-90310). In addition to being...

Luteolin is a polyphenolic flavone found in many plants including soybeans and perilla leaves. Luteolin is one of the most potent flavanoid inhibitors of soybean and reticulocyte 15-lipoxygenases, with an IC50 of 0.6 µM. Luteolin has also been found to inhibit the release of TNFalpha from neutrophils, and to inhibit...

PD 146176 is a potent and selective inhibitor of reticulocyte 15-lipoxygenase-1. It limits hypercholesterolemia-induced atherosclerosis in New Zealand White rabbits and reduces oxidant stress-induced apoptosis in endothelial cells. PD 146176 inhibits amyloid beta protein aggregate formation without changing total...

Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids. It is produced from eicosapentaenoic acid (EPA, Cay-90110, Cay-90110.1, Cay-21908) by 15-lipoxygenase (15-LO) via 15(S)-HpEPE (Cay-42710) and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human...

Yellow solid. Soluble in DMSO, DMF, methanol or ethanol. Slightly soluble in water. Anticancer and antimetastatic, alpha-Glucosidase inhibitor, Topoisomerase I Inhibitor, Apoptosis inducer, Anti-inflammatory, 15-Lipoxygenase (15-LOX) inhibitor, IL-6 production inhibitor, Fatty acid synthase (FAS) inhibitor,...

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PC is a phospholipid that contains stearic acid (Cay-10011298) at the sn-1 position and 15(S)-HpETE (Cay-44720) at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC, Cay-10009864) by 15-lipoxygenase (15-LO)....

1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (Cay-10011298) at the sn-1 position and 15(S)-HpETE (Cay-44720) at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE, Cay-25871) by 15-lipoxygenase (15-LO)....

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is a phospholipid that contains stearic acid (Cay-10011298) at the sn-1 position and 15(S)-HETE (Cay-34720) at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PC (SAPC, Cay-10009864) by 15-lipoxygenase (15-LO).Formal Name:...

BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1, IC50 = 32 nM in a cell-free enzyme assay). It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over...

NDGA is a non-selective lipoxygenase (LO) inhibitor which blocks cysteinyl leukotriene (CysLT) synthesis. NDGA inhibits A-23187-induced CysLT biosynthesis in rat peritoneal cells with an IC50 value of 5-7 µM. The IC50 values are 3.0-5.0 µM for human platelet 12-LO and 0.91 µM for rabbit reticulocyte 15-LO.Formal...

ALOX-15, also known as 15LOX-1, omega-6 lipoxygenase, or arachidonate 15-lipoxygenase (GenBank Accession No. NM_001140), a.a. 2- 662(end), with N-terminal FLAG-tag, MW=75 kDa, expressed in Sf9 insect cells via a baculovirus expression system.