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7-ethyl Camptothecin is a derivative of camptothecin (Cay-11694) and an anticancer agent. It inhibits wild-type but not Gly533 mutant topoisomerase I in RPMI-8402 and CPT-K5 cells, respectively (IC50s = 5.48 and >2,500 nM, respectively). 7-ethyl Camptothecin is cytotoxic to ADJ/PC6 SN-38-sensitive and PC6/SN2-5H2 SN-38-resistant cells (IC50s = 0.85 and 2.98 nM, respectively). In vivo, 7-ethyl camptothecin (0.25-3 mg/kg per day) increases survival in Ehrlich, MM46, Meth A, L1210, P388, and B16/F10 mouse ascites tumor models.Formal Name: (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione. CAS Number: 78287-27-1. Synonyms: SN-22. Molecular Formula: C22H20N2O4. Formula Weight: 376.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 1 mg/ml. lambdamax: 220, 254, 359 nm. SMILES: O=C1N2C(C3=NC4=CC=CC=C4C(CC)=C3C2)=CC5=C1COC([C@]5(O)CC)=O. InChi Code: InChI=1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1. InChi Key: MYQKIWCVEPUPIL-QFIPXVFZSA-N.
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