193 products were found matching "K03163"!

Coralyne is a DNA topoisomerase I poison. It inhibits DNA topoisomerase I via stabilization of the DNA-enzyme complex and inhibition of DNA relaxation. It is selective for DNA topoisomerase I over DNA topoisomerase II at 100 µg/ml. Coralyne (100-400 mg/kg) increases survival in P388 and L1210 murine leukemia...

Deruxtecan is a linker-payload conjugate made of a derivative of DX-8951 and the maleimide-GGFC peptide linker. It is used to synthetize ADCs (antibody drug conjugates), such as trastuzumab deruxtecan and patritumab deruxtecan. ADC (antibody drug conjugates) are a promising therapeutic strategy. ADCs are composed of...

Exatecan, also known as DX-8951, is a DNA topoisomerase I inhibitor. ADC (antibody drug conjugates) are a promising therapeutic strategy. ADCs are composed of an antibody that can bind to a target in the cells, such as HER3 (human epidermal growth factor receptor 3), a linker and a payload (cytotoxic drug)....

DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...

Description: TOP1 Protein, Mouse, Recombinant (aa 193-767, His) is expressed in Baculovirus-Insect Cells. The accession number is Q04750.

Exatecan is a DNA topoisomerase I inhibitor that inhibits cancer cell growth in vitro and reduces tumor growth in vivo. It has been used as the cytotoxic payload component of antibody-drug conjugates (ADCs), which have been used to selectively target and destroy cancer cells in vitro and in vivo in animal models....

Immunogen: Exatecan-KLH  Host: Rabbit  Species Reactivity: Species independent  Cross Reactivity: (+++) Exatecan, (++) Deruxtecan, (-) Other warheads  Applications: ELISA, WB. SMILES: . InChi Code: . InChi Key:

Exatecan-amide-cyclopropanol is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) that has been used as a building block in the synthesis of antibody-drug conjugates (ADCs) with anticancer activity. Formal Name:...

Mal-PEG8-Val-Ala-PAB-Exatecan is a reactive drug-linker molecule containing the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a maleimide-terminal linker. Formal Name:...

Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. TOP1MT antibody detects DNA topoisomerase 1 mitochondrial, encoded by the TOP1MT gene. DNA topoisomerase 1 mitochondrial is an enzyme located in the mitochondrial matrix that relaxes supercoiled mitochondrial DNA, enabling replication,...

Ac-Exatecan is an acetylated derivative of exatecan (Cay-35452), a DNA topoisomerase I inhibitor. InChI: InChI=1S/C26H24FN3O5/c1-4-26(34)16-7-20-23-14(9-30(20)24(32)15(16)10-35-25(26)33)22-18(28-12(3)31)6-5-13-11(2)17(27)8-19(29-23)21(13)22/h7-8,18,34H,4-6,9-10H2,1-3H3,(H,28,31)/t18-,26-/m0/s1 InChIKey:...

Topotecan is an inhibitor of DNA topoisomerase I and a derivative of the DNA topoisomerase I inhibitor camptothecin (Cay-11694). Topotecan inhibits DNA topoisomerase I in human MCF-7 breast and DU-145 prostate cancer cells with IC50 values of 13 and 2 nM, respectively, in a cell-based luciferase reporter assay....