165 products were found matching "K03163"!
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Camptothecin
Item number: Cay11694-50
DNA topoisomerases relax DNA torsional strain created during replication, transcription, recombination, repair, and chromosome condensation. The relaxation of DNA supercoiling by topoisomerase I at single-strand breaks enables anticancer agents to reversibly trap the complex by intercalating between DNA base pairs...
| Keywords: | MAG-CPT, NSC 94600, (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Application: | Topoisomerase inhibitor |
| CAS | 7689-03-4 |
| MW: | 348.4 D |
From 36.00€
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DNA topoisomerase 1 (TOP1), recombinant human
Item number: CSB-BP024056HU.1
Organism: Homo sapiens (Human). Source: Baculovirus. Expression Region: 2-765aa. Protein Length: Full Length of Mature Protein. Tag Info: C-terminal 10xHis-tagged. Target Protein Sequence: SGDHLHNDSQ IEADFRLNDS HKHKDKHKDR EHRHKEHKKE KDREKSKHSN SEHKDSEKKH KEKEKTKHKD GSSEKHKDKH KDRDKEKRKE EKVRASGDAK IKKEKENGFS...
| Keywords: | TOP1, DNA topoisomerase 1, DNA topoisomerase I |
| Application: | Activity not tested |
| Expressed in: | Insect cells |
| Origin: | human |
| MW: | 92.0 kD |
From 489.00€
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Anti-TOP1
Item number: ABS-KC-1608.100
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
| Keywords: | Anti-DNA topoisomerase 1, Anti-DNA topoisomerase I, TOP1 Antibody |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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Anti-TOP1
Item number: ABS-KC-1609.100
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
| Keywords: | Anti-DNA topoisomerase 1, Anti-DNA topoisomerase I, TOP1 Antibody |
| Host: | Mouse |
| Species reactivity: | human |
From 232.00€
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Anti-TOP1
Item number: ABS-KC-900.100
Protein function: Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is...
| Keywords: | Anti-DNA topoisomerase 1, Anti-DNA topoisomerase I, TOP1 Antibody |
| Application: | IHC |
| Host: | Mouse |
| Species reactivity: | human |
From 206.00€
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Dxd
Item number: Cay41699-10
Dxd is a derivative of the DNA topoisomerase I inhibitor exatecan (Cay-35452) and a starting material that has been used in the synthesis of antibody-drug conjugates (ADCs). It has been used in the synthesis of ADCs targeting HER2 with anticancer activity in vitro and in vivo.Formal Name:...
| Keywords: | N-[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indol... |
| Application: | Exatcan (DNA topoisomerase I inhibitor) derivative, ADC synthesis starting material |
| CAS | 1599440-33-1 |
| MW: | 493.5 D |
From 90.00€
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Irinotecan
Item number: TGM-T6228-10mg
Description: Irinotecan (CPT-11), a derivative of camptothecin, is an inhibitor of DNA topoisomerase I (Topo I). Irinotecan has antitumor activity by preventing DNA strand reattachment through binding to the Topo I complex, resulting in double-stranded DNA breaks and cell death. Target: Topoisomerase, Autophagy....
| Keywords: | CPT-11, Topotecin, (+)-Irinotecan |
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 97682-44-5 |
| MW: | 586.68 D |
From 30.00€
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Lurtotecan dihydrochloride
Item number: TGM-T70445-100mg
Description: Lurtotecan dihydrochloride is an antineoplastic (DNA Topoisomerase I Inhibitor). Target: Others. Smiles: Cl.Cl.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc5OCCOc5cc4c(CN4CCN(C)CC4)c3Cn1c2=O
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 155773-58-3 |
| MW: | 591.486 D |
From 2,573.00€
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Genz-644282
Item number: TGM-T7187-100mg
Description: Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment. Target: Topoisomerase. Smiles: CNCCn1c2c3cc4OCOc4cc3ncc2c2cc(OC)c(OC)cc2c1=O. References: Kurtzberg L S , Roth S , Krumbholz R , et al. Genz-644282, a Novel Non-Camptothecin Topoisomerase I Inhibitor for Cancer...
| Keywords: | Genz644282 |
| Application: | Topoisomerase I (TOP1) inhibitor |
| CAS | 529488-28-6 |
| MW: | 407.42 D |
From 42.00€
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Belotecan hydrochloride
Item number: TGM-T7551-100mg
Description: Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity. Target: Topoisomerase. Smiles: Cl.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4ccccc4c(CCNC(C)C)c3Cn1c2=O. References: Kim Y K , Koo N Y , Yun P Y . Anticancer...
| Keywords: | CKD-602 |
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 213819-48-8 |
| MW: | 469.96 D |
From 40.00€
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Sacituzumab govitecan
Item number: TGM-T77824-5mg
Description: Sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) targeting Trop-2, facilitates the delivery of SN-38. It demonstrates anticancer activity [1]. Target: Antibody-Drug Conjugates (ADCs), Others. Smiles:...
| Keywords: | IMMU-132 |
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 1491917-83-9 |
| MW: | 160 kD |
1,360.00€
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Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan
Item number: TGM-T77842-50mg
Description: Mal-PEG8-amide-Val-Ala-(4-NH2)-Exatecan is a conjugated compound used in the synthesis of antibody-drug conjugates (ADCs), featuring a topoisomerase inhibitor derivative linked via a linker to a specific ligand unit[1]. Target: Others, Drug-Linker Conjugates for ADC. Smiles:...
| Application: | Targets DNA topoisomerase I [EC:5.6.2.1] (TOP1) |
| CAS | 2495742-34-0 |
| MW: | 1148.26 D |
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