5,6-dihydro-5-Fluorouracil
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5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug... more
Product information "5,6-dihydro-5-Fluorouracil"
5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Cay-14416). It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of 5,6-dihydro-5-fluorouracil (90 mg/kg per week), in combination with 5-fluorouracil and the DPD inhibitor eniluracil (Cay-34251), reduces tumor growth in a rat model of colon carcinoma.Formal Name: 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione. CAS Number: 696-06-0. Synonyms: 5-DHFU, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-Fluoro-5,6-dihydrouracil, 5-FUH2. Molecular Formula: C4H5FN2O2. Formula Weight: 132.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 60 mg/ml, DMSO: 53 mg/ml, Ethanol: 0.8 mg/ml, PBS (pH 7.2): 8 mg/ml. lambdamax: 203 nm. SMILES: O=C1NC(NCC1F)=O. InChi Code: InChI=1S/C4H5FN2O2/c5-2-1-6-4(9)7-3(2)8/h2H,1H2,(H2,6,7,8,9). InChi Key: RAIRJKWTBBDDAR-UHFFFAOYSA-N.
| Keywords: | 5-DHFU, 5-Fluoro-5,6-dihydrouracil, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-FUH2, 5-fluorodihydro-2,4(1H,3H)-pyrimidinedione |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 20977 |
Properties
| Application: | Apoptosis inducer |
| MW: | 132.1 D |
| Formula: | C4H5FN2O2 |
| Purity: | >95% |
| Format: | Crystalline Solid |
Database Information
| CAS : | 696-06-0| Matching products |
| KEGG ID : | K00560 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P312, P321, P330, P301+P310, P302+P352, P304+P340, P305+P351+P338, P332+P313, P337+P313, P362+P364, P405, P403+P233, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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