- Search results for K00560
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76 products were found matching "K00560"!
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Item number: ELK-ELK4158.48
The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TYMS. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TYMS. Next,...
Keywords: | TS, TSase, Thymidylate synthase |
Application: | ELISA |
Species reactivity: | human |
From 365.00€
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Item number: Cay14416-5
5-Fluorouracil (5-FU) is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP). It is also converted to the active metabolites FUTP and FdUTP, which induce RNA and DNA damage, respectively. In vivo, 5-FU (15 mg/kg) when administered in combination with docetaxel (Cay-11637) reduces tumor...
Keywords: | 5-FU, NSC 19893, Ro 2-9757, U-8953, 5-fluoro-2,4(1H,3H)-pyrimidinedione |
Application: | Apoptosis inducer, Thymidylate synthase inhibitor |
CAS | 51-21-8 |
MW: | 130.1 D |
From 44.00€
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Item number: 100-401-199
This antiserum is directed against human Thymidylate Synthase and is useful in determining its presence in various assays. Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine...
Keywords: | Anti-TS, Anti-TYMS, Anti-TSase, EC=2.1.1.45, Anti-Thymidylate synthase |
Application: | ELISA, IHC, WB |
Host: | Rabbit |
Species reactivity: | human |
684.00€
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Item number: Cay20526-1
(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in...
Keywords: | Tetrahydrofolate, THFA, N-[4-[[(2-amino-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid,... |
Application: | Tetrahydrofolic acid diastereomer |
CAS | 150731-85-4 |
MW: | 554.8 D |
From 54.00€
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Item number: Cay20977-10
5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Cay-14416). It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of...
Keywords: | 5-DHFU, 5-Fluoro-5,6-dihydrouracil, 5-Fluorodihydropyrimidine-2,4-dione, 5-Fluorodihydrouracil, 5-FUH2,... |
Application: | Apoptosis inducer |
CAS | 696-06-0 |
MW: | 132.1 D |
From 119.00€
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Item number: Cay14154-50
Floxuridine is an active metabolite of the fluorodeoxyuridylate (FdUMP) prodrug 5-fluorouracil (5-FU, Cay-14416). It is formed from 5-FU by thymidine phosphorylase, which is then phosphorylated by thymidine kinase to form FdUMP. Floxuridine (1 µM) induces DNA double-strand breaks in thymidylate synthase-deficient...
Keywords: | 5-FDU, 5-Fluorodeoxyuridine, NSC 26740, NSC 27640, 2'-deoxy-5-fluoro-uridine |
Application: | Anticancer agent |
CAS | 50-91-9 |
MW: | 246.2 D |
From 69.00€
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Item number: Cay21366-100
Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.Formal Name: alpha,alpha,alpha-trifluoro-thymidine. CAS Number: 70-00-8....
Keywords: | NSC 529182, NSC 75520, TFT, Trifluridine, alpha,alpha,alpha-trifluoro-thymidine |
Application: | Thymidylate synthase inhibitor |
CAS | 70-00-8 |
MW: | 296.2 D |
From 142.00€
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Item number: Cay14269-10
Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased...
Keywords: | N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, disodium salt,... |
Application: | Antifolate |
CAS | 357166-29-1 |
MW: | 597.5 D |
From 82.00€
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Item number: Cay26079-10
Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM). It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg,...
Keywords: | ICI-D 1694, ZD 1694, N-[[5-[[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic... |
Application: | Antineoplastic, Thymidylate synthase inhibitor |
CAS | 112887-68-0 |
MW: | 458.5 D |
From 84.00€
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Item number: Cay26683-1
5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-fluorouracil (5-FU, (Cay-14416) by GC- or LC-MS. 5-FU is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP). It is also converted to the active metabolites FUTP and FdUTP, which induce RNA...
Keywords: | 5-FU-13C,15N2, 5-fluoro-2,4(1H,3H)-pyrimidinedione-2-13C-1,3-15N2 |
Application: | GC-MS, LC-MS, quantification, internal standard, thymidylate synthase inhibitor |
CAS | 1189423-58-2 |
MW: | 133.1 D |
448.00€
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Item number: Cay33967-5
Folitixorin is a reduced form of folate and cofactor for thymidylate synthetase, the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). It forms a ternary complex with thymidylate synthetase and fluorodeoxyuridylate (FdUMP), the active metabolite of...
Keywords: | 5,10-methyl THF, 5,10-Methylenetetrahydrofolic Acid,... |
Application: | Reduced folate form, Thymidylate synthetase cofactor, Antineoplastic (enhancer) |
CAS | 3432-99-3 |
MW: | 457.4 D |
488.00€
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Item number: ARG55844.100
Protein function: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. [The UniProt Consortium]
Keywords: | Anti-TS, Anti-TYMS, Anti-TSase, EC=2.1.1.45, Anti-Thymidylate synthase |
Application: | WB, IHC (paraffin), FC, ICC, IF |
Host: | Rabbit |
Species reactivity: | human |
584.00€
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