134 products were found matching "K00560"!

Thymidylate synthase (TS) is a key enzyme in the synthesis of 2'-deoxythymidine-5'-monophosphate, an essential precursor for DNA biosynthesis. Thymine nucleotide synthase is a key enzyme in the de novo synthesis pathway of mitochondrial thymine. For this reason, it is a key target for cancer chemotherapy, and...

Folitixorin is a reduced form of folate and cofactor for thymidylate synthetase, the enzyme that catalyzes the methylation of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP). It forms a ternary complex with thymidylate synthetase and fluorodeoxyuridylate (FdUMP), the active metabolite of...

This antiserum is directed against human Thymidylate Synthase and is useful in determining its presence in various assays.  Because inhibition of Thymidylate Synthase prevents DNA synthesis and cell proliferation, the enzyme is an important target for cancer chemotherapeutic drugs, specifically the fluoropyrimidine...

5,6-dihydro-5-Fluorouracil is an active metabolite of the thymidylate synthase inhibitor prodrug 5-fluorouracil (Cay-14416). It is formed from 5-fluorouracil by dihydropyrimidine dehydrogenase (DPD). 5,6-dihydro-5-Fluorouracil is cytotoxic to HaCaT keratinocytes (IC50 = 13.5 µM). Intravenous administration of...

(6R,S)-5,6,7,8-Tetrahydrofolic acid (THFA), the reduced form of folic acid, serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism. Its metabolites participate in the synthesis of thymidine for incorporation into DNA or the synthesis of purines, as well as in...

Floxuridine is an active metabolite of the fluorodeoxyuridylate (FdUMP) prodrug 5-fluorouracil (5-FU, Cay-14416). It is formed from 5-FU by thymidine phosphorylase, which is then phosphorylated by thymidine kinase to form FdUMP. Floxuridine (1 µM) induces DNA double-strand breaks in thymidylate synthase-deficient...

Trifluorothymidine is a derivative of thymidine that exhibits antiviral and anticancer activity by inhibiting thymidylate synthase, thereby blocking nucleic acid synthesis, and by incorporating into DNA, which leads to DNA damage and apoptosis.Formal Name: alpha,alpha,alpha-trifluoro-thymidine. CAS Number: 70-00-8....

Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase (Kis = 109 and 7 nM, respectively, for the human recombinant enzymes), and the potency for thymidylate kinase is increased...

Raltitrexed is an inhibitor of thymidylate synthase (Ki = 62 nM). It inhibits the growth of L1210 mouse lymphocytic leukemia cells in vitro (IC50 = 8 nM) as well as reduces thymidylate synthase activity and completely eliminates tumors in a mouse L1210:ICR ascitic tumor model when administered at a dose of 4 mg/kg,...

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-fluorouracil (5-FU, (Cay-14416) by GC- or LC-MS. 5-FU is a prodrug form of the thymidylate synthase inhibitor fluorodeoxyuridylate (FdUMP). It is also converted to the active metabolites FUTP and FdUTP, which induce RNA...

Pemetrexed-13C5 is intended for use as an internal standard for the quantification of pemetrexed (Cay-14269) by GC- or LC-MS. Pemetrexed is an antifolate with anticancer activity. It is an inhibitor of folate-dependent enzymes involved in purine synthesis, including thymidylate synthase and dihydrofolate reductase...

Description: Capecitabine (Capecitibine) is a fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU), subsequently, 5-FU is metabolized to two active...