4'-Demethylpodophyllotoxin

4'-Demethylpodophyllotoxin is a lignan that has been found in D. versipellis and has microtubule assembly inhibitory and anticancer activities. It inhibits the assembly of isolated chicken brain tubulin (IC50 = 0.5 µM) and the proliferation of LNCaP and PC3 prostate cancer cells (IC50s = 0.056 and 0.082 µM, respectively).Formal Name: (5R,5aR,8aR,9R)-5,8,8a,9-tetrahydro-9-hydroxy-5-(4-hydroxy-3,5-dimethoxyphenyl)-furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one. CAS Number: 40505-27-9. Molecular Formula: C21H20O8. Formula Weight: 400.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. SMILES: O=C1[C@]2([H])[C@@](C3=CC(OC)=C(C(OC)=C3)O)([H])C4=CC(OCO5)=C5C=C4[C@@H]([C@@]2([H])CO1)O. InChi Code: InChI=1S/C21H20O8/c1-25-15-3-9(4-16(26-2)20(15)23)17-10-5-13-14(29-8-28-13)6-11(10)19(22)12-7-27-21(24)18(12)17/h3-6,12,17-19,22-23H,7-8H2,1-2H3/t12-,17+,18-,19-/m0/s1. InChi Key: YVCVYCSAAZQOJI-BTINSWFASA-N. Origin: Plant/Dysosma versipellis.