GR (Mouse) Reporter Assay System

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
IB-M00201	96 wells (1 x 96 -well format assays)		-		7 - 14 business days*		1,588.00€
IB-M00201-32	96 wells (3 x 32 assays in 96 -well format)		-		7 - 14 business days*		1,705.00€

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Protein function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a... more

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Product information "GR (Mouse) Reporter Assay System"

Protein function: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:10678832). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (PubMed:15037546). [The UniProt Consortium]