Anti-phospho-TERT (Tyr707) (Telomerase Reverse Transcriptase, Telomerase Catalytic Subunit, HEST2, T

Anti-phospho-TERT (Tyr707) (Telomerase Reverse Transcriptase, Telomerase Catalytic Subunit, HEST2, T
Item number Size Datasheet Manual SDS Delivery time Quantity Price
T2399-25E.200 200 µl - -

4 - 22 business days

557.00€
 
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in... more
Product information "Anti-phospho-TERT (Tyr707) (Telomerase Reverse Transcriptase, Telomerase Catalytic Subunit, HEST2, T"
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [The UniProt Consortium]
Keywords: EC=2.7.7.49, Anti-phospho-Telomerase catalytic subunit, Anti-phospho-Telomerase-associated protein 2, Anti-phospho-Telomerase reverse transcriptase
Supplier-Nr: T2399-25E

Properties

Application: ELISA, Dot Blot
Antibody Type: Polyclonal
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic phosphopeptide corresponding to amino acid residues surrounding Y707 of human TERT (KLH).
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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