103 products were found matching "K11126"!

Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the...

Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse TERT. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TERT. Next,...

Cycloastragenol, the aglycone derivative of astragaloside A (Cay-16677), can be found in various species of Astragalus and is reported to activate telomerase. It has been shown to slow telomere loss, increase replicative capacity, and improve immune function in CD8+ T lymphocytes from HIV-1-infected patients.Formal...

Description: Imetelstat is a 13-mer oligonucleotide that binds with high affinity to the template region of the RNA component of human telomerase, acting as a competitive inhibitor of telomerase enzymatic activity, and is extensively used in cancer and aging research to investigate telomere maintenance, cellular...

In 1X PBS, pH 7.4, with 0.09% sodium azide. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for...

BIBR 1532 is a mixed-type non-competitive inhibitor of telomerase (IC50 = 93 nM) that has little effect on several mammalian DNA and RNA polymerases, bacterial DNA helicase, or HIV-1 reverse transcriptase. It specifically targets the telomerase reverse transcriptase catalytic subunit, TERT. Through its effects on...

Antibiotic, HIV-1 reverse transcriptase inhibitor, Human telomerase inhibitor, Cytostatic against different tumor cell lines. Isolated from Streptomyces sp.

TMPyP4 is a cationic porphyrin that intercalates into and stabilizes G-quadruplexes, which are formed by DNA and RNA sequences composed of blocks of guanine residues. In this way, TMPyP4 inhibits telomerase activity (IC50 = 50 µM), blocking the clonogenic growth and migration of cancer cells in culture and in vivo....

A potential male anti-fertility agent from cotton that exhibits a wide spectrum of toxicity. It was found to have cytotoxic effects on human cancer cell lines. It is a potent telomerase inhibitor.

Antibiotic, HIV-1 reverse transcriptase and human telomerase inhibitor, Antibacterial, Cytostatically active against different tumor cell lines. Isolated from Streptomyces sp.

Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 µM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 µM) in endometriotic epithelial cells and STAT3 activation...