Anti-phospho-TERT (Ser1125)

Anti-phospho-TERT (Ser1125)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-F48565-0.08ML 80 µl - -

3 - 10 business days

207.00€
NSJ-F48565-0.4ML 400 µl - -

3 - 10 business days

503.00€
 
In 1X PBS, pH 7.4, with 0.09% sodium azide. Telomerase is a ribonucleoprotein polymerase that... more
Product information "Anti-phospho-TERT (Ser1125)"
In 1X PBS, pH 7.4, with 0.09% sodium azide. Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Protein function: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA- dependent extension of 3'-chromosomal termini with the 6- nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis. [The UniProt Consortium]
Keywords: Anti-phospho-TP2, Anti-phospho-EST2, Anti-phospho-TERT, Anti-phospho-HEST2, EC=2.7.7.49, Anti-phospho-Telomerase catalytic subunit, Anti-phospho-Telomerase-associated protein 2, Anti-phospho-Telomerase reverse transcriptase, Phospho-TERT Antibody (pS1125)
Supplier: NSJ Bioreagents
Supplier-Nr: F48565-0.08ML

Properties

Application: Dot Blot, ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: This phospho-TERT antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1125 of human TERT.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-TERT (Ser1125)"
Write a review
or to review a product.
Viewed