Anti-phospho-SGK3, (Thr320) (Serine/Threonine-protein Kinase Sgk3, Serum/Glucocorticoid-regulated K

Anti-phospho-SGK3, (Thr320) (Serine/Threonine-protein Kinase Sgk3, Serum/Glucocorticoid-regulated K
Item number Size Datasheet Manual SDS Delivery time Quantity Price
S1010-85W8.100 100 µl - -

3 - 19 business days*

757.00€
 
Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to... more
Product information "Anti-phospho-SGK3, (Thr320) (Serine/Threonine-protein Kinase Sgk3, Serum/Glucocorticoid-regulated K"
Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt. SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways. Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation. SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK is negatively regulated by ubiquitination and proteasome degradation. SGK3 has been shown to be a downstream signaling molecule in the PI3K pathway. Its activation and phosphorylation at Thr320 by PDK1 may be an Akt-independent manner of signaling in cancer. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000. Incubate membrane with diluted antibody in 1X TBS, 5% BSA, 0.1% Tween-20 at 4ºC with gentle shaking, overnight., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-CISK, EC=2.7.11.1, Anti-Serine/threonine-protein kinase Sgk3, Anti-Cytokine-independent survival kinase, Anti-Serum/glucocorticoid-regulated kinase 3, Anti-Serum/glucocorticoid-regulated kinase-like
Supplier: United States Biological
Supplier-Nr: S1010-85W8

Properties

Application: WB
Antibody Type: Monoclonal
Clone: D30E6
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Synthetic phosphopeptide corresponding to residues surrounding Thr320 of human SGK3.
Format: Supernatant

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-phospho-SGK3, (Thr320) (Serine/Threonine-protein Kinase Sgk3, Serum/Glucocorticoid-regulated K"
Write a review
or to review a product.
Viewed