Anti-phospho-RPA32 (Ser4/Ser8) Recombinant Monoclonal

Anti-phospho-RPA32 (Ser4/Ser8) Recombinant Monoclonal
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A700-009-T 20 µl (2 blots) -

3 - 9 business days

125.00€
A700-009 100 µl (10 blots) -

3 - 9 business days

290.00€
 
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds... more
Product information "Anti-phospho-RPA32 (Ser4/Ser8) Recombinant Monoclonal"
Protein function: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance. [The UniProt Consortium]
Keywords: Anti-phospho-RPA2, Anti-phospho-REPA2, Anti-phospho-RP-A p34, Anti-phospho-RP-A p32, Anti-phospho-RF-A protein 2, Anti-phospho-Replication factor A protein 2, Anti-phospho-Replication protein A 32 kDa subunit
Supplier-Nr: A700-009-T

Properties

Application: WB, IP
Antibody Type: Monoclonal
Host: Rabbit
Reactivity: Human
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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